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In a study where paroxetine 30 mg qd was dosed orally for 4 weeks, steady-state plasma concentrations of paroxetine were increased by approximately 50 during coadministration with oral cimetidine 300 mg tid for the final week.

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Take certain medicines including selective serotonin reuptake inhibitors ssris such as fluoxetine, sertraline, or paroxetine; serotonin and norepinephrine reuptake inhibitors snri such as venlafaxine or duloxetine; clomipramine or imipramine tricyclic antidepressants ; meperidine, tramadol, methadone, pentazocine, propoxyphene opioid medicines ; dextromethorphan; or carbamazepine are less than 12 years of age have a tumor on your adrenal gland called a pheochromocytoma.

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Serotonin-selective reuptake inhibitors ssris , a newer group of antidepressants that includes drugs such as fluoxetine prozac , sertraline zoloft and paroxetine paxil , cause little weight gain and may even contribute to weight loss.

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